Tirzepatide (B6/B12)
An FDA-approved active researched for weight management and metabolic health, with some of the largest effect sizes seen in modern obesity trials — compounded with B6/B12.
| Concentration | 5–30 mg/0.5 mg/1 mL (2 mL vial) |
Available strengths
- 2.5 mg dose · 10 mg
- 5.0 mg dose · 20 mg
- 7.5 mg dose · 30 mg
- 10 mg dose · 40 mg
- 12.5 mg dose · 50 mg
- 15 mg dose · 60 mg
- 3-month bundle · months 1–3 · 60 mg total
- 3-month bundle · months 4–6 · 150 mg total
Your physician determines the appropriate strength and titration.
Member pricing
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About Tirzepatide (B6/B12)
The honest rundown
Straight information, no hype — so your conversation with a physician starts from the truth.
Tirzepatide is a dual GIP/GLP-1 receptor agonist — one molecule that engages two of the body's appetite- and blood-sugar-regulating pathways at once. Its active ingredient has been studied in large, modern human trials, where it produced some of the biggest effect sizes seen in obesity and metabolic research.
The partner 503A pharmacy compounds it with B6 and B12. It's a serious, physician-managed therapy — not a shortcut — and it works best alongside the nutrition, training, and coaching that make results last. A licensed physician decides whether it's right for you and owns your dose and titration schedule.
How it works
What the science actually looks at
GLP-1 pathway
Like semaglutide, it acts on GLP-1 receptors tied to satiety and hunger signaling.
GIP pathway
It also engages GIP receptors — the second pathway researchers credit for its larger effect sizes in trials.
Gastric emptying
It slows stomach emptying, which is studied for its role in feeling satisfied longer.
B6 / B12
The pharmacy's formulation adds B6 and B12, vitamins some providers pair with GLP-1 therapy.
Who it's for
Who tends to look into this
- People pursuing significant, medically-supervised weight loss
- Those who've plateaued on diet, exercise, or a prior GLP-1
- Anyone who wants coaching and accountability alongside therapy
- Candidates ready for a doctor-reviewed, longer-term plan
The approach
Possible duration & dosing
Duration
A longer-term therapy your physician reviews over time — not a quick course.
How it's given
A once-weekly subcutaneous injection.
Your dose
Your physician starts low and steps the dose up gradually. The schedule is theirs to set — never self-adjusted.
With every order
What's included
- A consultation with our physician-led team
- A doctor-reviewed medical history and a plan personalized to you
- Temperature-controlled shipping with tracking on every order
- Complete supplies — syringes, alcohol wipes, and clear instructions
- TCO Wellness supports you with messaging access and new orders
Realistic view
Possible expectations
The honest baseline
Tirzepatide produced some of the largest effects in modern trials, but trial averages aren't a promise for any one person.
Early weeks
As the dose is titrated up, reduced appetite is the common early signal — with digestive side effects possible alongside it.
Over the months
Body-composition and metabolic changes tend to unfold over months, and lifestyle still does much of the work. No outcome is guaranteed.
Keeping it right
Storage & handling
- Keep it cool and out of direct light — refrigerate unless your instructions say otherwise
- Follow the storage and handling directions that ship with your order
- If anything looks off — cloudy, discolored, or past date — check with your provider before using
- Dispose of any needles and syringes in a proper sharps container
Questions
Common questions
How is it different from semaglutide?
Tirzepatide works on two receptors (GIP and GLP-1) rather than one, which is linked to larger effect sizes in trials. Which one suits you is a question for your physician.
Is it the same as Mounjaro or Zepbound?
Same active ingredient, but the version available through TCO programs is a compounded B6/B12 formulation from a state-licensed 503A pharmacy — not the branded, FDA-approved product.
What about side effects?
Digestive effects are most common, particularly early and when stepping up a dose — a normal part of the physician conversation.
How is it taken?
A once-weekly subcutaneous injection at a physician-set dose. Syringes, alcohol wipes, and instructions ship with every order.
Before you ask
Worth knowing
- The active is FDA-approved; the pharmacy-compounded B6/B12 version is not FDA-reviewed.
- Not for use in pregnancy, or with a personal or family history of medullary thyroid cancer or MEN2 — tell your physician.
- Dosing steps up gradually and is owned by your provider, never self-managed.
- Best paired with the nutrition and coaching included in every program.
How it's made
Quality & compliance
- Prescribed only by an independent licensed physician after reviewing your medical history
- Compounded and dispensed by a state-licensed 503A compounding pharmacy
- Prepared patient-specific — compounded medications are not FDA-approved products
- Backed by coaching and concierge support the whole way through
Educational information only — not medical advice, and not a claim of results. Whether any therapy is right for you, and at what dose, is determined solely by an independent licensed physician after reviewing your medical history.
How it works at TCO
No therapy is a product you simply buy
An independent licensed physician reviews your history and determines whether therapy is appropriate. Want to talk it through with the doctor directly? We'll set that up.If approved, your order is fulfilled by a state-licensed 503A compounding pharmacy with temperature-controlled shipping and every supply included — and you're coached throughout your journey.
Prescription products require an evaluation with a licensed medical professional, who will determine whether a prescription is appropriate. Compounded medications are prepared by a state-licensed 503A compounding pharmacy and are not FDA-approved; the FDA does not review compounded medications for safety or effectiveness.
TCO Wellness is a wellness and concierge-care company — we do not practice medicine. All prescriptions are issued by independent licensed physicians after review of your medical history, and medications are compounded and dispensed by a state-licensed 503A compounding pharmacy. Individual results vary.